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Title: | Study on some hepatic functions and prevalence of hepatitis B surface antigenaemia in Egyptian children with schistosomal hepatic fibrosis |
Authors: | Hammad, Hassan A. Fattah, Mohamed M. Zbd el Moris, Magid |
Year: | 1990 |
Periodical: | Journal of Tropical Pediatrics |
Volume: | 36 |
Issue: | 3 |
Pages: | 126-127 |
Language: | English |
Geographic term: | Egypt |
Subjects: | child health liver diseases schistosomiasis |
External link: | http://tropej.oxfordjournals.org/cgi/content/abstract/36/3/126 |
Abstract: | Several different hepatic parenchymal lesions, including chronic hepatitis and cirrhosis, have been increasingly reported in children with schistosomal hepatic fibrosis (SHF) despite the known mesenchymal nature of the disease. The prevalence of persistent hepatitis (B) surface (HBs) antigenaemia and some hepatic functions have been determined in 52 children with SHF, aged between 5 and 15 years and chosen from the outpatient clinics of Alexandria University Children's Hospital and Damanhour Teaching Hospital, Egypt, as well as in 100 age-matched healthy children. High prevalence of chronic HBs antigenaemia (58 percent) has been demonstrated in children with SHF, but only in 2 percent of the normal children. This denotes that children with SHF represent a dangerous reservoir for hepatitis B infection to the community. Serum alanine transferase (ALT) was higher than normal in 58 percent of HBS seropositive patients and in none of the seronegative patients. This points to the risk of continual hepatic parenchymal injury to the HBs seropositive patients with schistosomiasis. Ref. |