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Periodical article Periodical article Leiden University catalogue Leiden University catalogue WorldCat catalogue WorldCat
Title:HIV pre-exposure prophylaxis trials: socio-economic and ethical perspectives for sub-Saharan Africa
Author:Selemogo, MphoISNI
Year:2008
Periodical:African Journal of AIDS Research
Volume:7
Issue:2
Pages:243-247
Language:English
Geographic term:Subsaharan Africa
Subjects:AIDS
preventive medicine
ethics
medical research
External link:https://www.tandfonline.com/doi/abs/10.2989/AJAR.2008.7.2.10.527
Abstract:HIV-prevention work needs stepping up and new and acceptable avenues to achieve this are needed. One potential modality currently being explored is HIV pre-exposure prophylaxis (PrEP), which is the scientifically plausible idea that a daily dose of an antiretroviral drug taken by an HIV-negative person who may otherwise be at risk of acquiring HIV could potentially reduce his or her chances of contracting the virus. The advent of HIV pre-exposure prophylaxis (PrEP) as an HIV-prevention strategy has received optimistic support among HIV researchers. However, discourse on PrEP trials has tended to be dominated by the disputes arising between some activist groups and researchers about the research methodologies. Instead, this paper discusses other issues oftentimes neglected in discussions relating to PrEP trials. Specifically, it focuses on the possible ethical implications and the potential impact of sub-Saharan Africa's socioeconomic conditions on the promised benefits of PrEP trials for the region and the continent. It argues that the concept of PrEP as an affordable and practical HIV-prevention intervention presents challenges and questions that urgently need addressing as we await results from several ongoing trials. If research is undertaken with no plans on how the results of specific trials can render actual HIV-prevention benefits - especially for the world's poor - then such endeavours risk being merely information-acquiring ventures. Bibliogr., notes, ref., sum. [Journal abstract, edited]
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