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Title:Phytochemical investigation on Namibian plants for anti-malaria compounds
Authors:Du Preez, Iwanette
Mumbengegwi, Davis
Periodical:Journal for Studies in Humanities and Social Sciences (ISSN 2026-7215)
Geographic term:Namibia
Subjects:medicinal plants
preventive medicine
Abstract:To facilitate integration of traditional treatments into mainstream malaria case management, a study was conducted to identify, document and validate the presence of selected classes of compounds with anti-plasmodial activity in seven ethnomedicinal plants native to Namibia: Vahlia capensis, Nicolasia costata, Rhigozum brevispinosum, Dicerocaryum eriocarpum, Senna occidentalis, Lophiocarpus sp. and Crotalaria flavicarinata. The plants were selected on the basis of indigenous use that suggests their toxicity to Plasmodium parasites. Crude extracts were prepared using methanol-dichloromethane and distilled water. The extracts were further partitioned with chloroform-methanol-water. Phytochemical tests revealed the presence of anthraquinones, flavonoids, terpenoids, coumarines, and glycosides; alkaloids and steroids were not detected. Paradoxically, thin-layer chromatography analysis on the crude extracts of the same plants tested positive for all compounds. The presence of these phytochemicals and the data generated support the ethno-medicinal uses for these plants. Bibliogr., sum. [Journal abstract, edited]